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Interferon Gamma are members of the Type II class of interferons. Type II IFN in humans is limited to the single IFN-Gamma gene. This IFN binds to the Type II receptor comprised of IFNGR1 and IFNGR2 chains. IFN-Gamma is produced by cells of the immune system such as B-cells, T-cells and NK cells. IFN-Gamma is glycosylated in mammalian cells, and the active form functions as a homodimer. All PBL Interferon-Gamma proteins are guaranteed dimers for maximum activity.
Joouen et al. (2005) Clin. Cancer Res. 11:1629 "Identification of CD19 and CD20 Peptides for Induction of Antigen-Specific CTLs against B-Cell Malignancies"
Petr et al. (2006) J. Virol. 80:7146 "CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) in vitro and Immune Response to EMCV Infection in vivo"
IFN-Gamma Proteins
Burdeinick-Kerr et al. (2005) J. Virol. 79:5374 "Gamma Interferon-Dependent, Noncytolytic Clearance of Sindbis virus Infection from Neuron in vitro"
Jin et al. (2006) PNAS. 102:9294 "Robust Hepatitis C virus infection in vitro"
Antibodies to IFN-Gamma
Ahmed et al. (2006) J. Immunol. 177:315 "IFN-gamma and Its Receptor Subunit IFNGR1 Are Recruited to the IFN-gamma-Activated Sequence Element at the Promoter Site of IFN-gamma-Activated Genes: Evidence of Transcational Activity of IFNGR1"
Michitaka et al. (2007) J. Neurosci. 27:1879 "Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann-Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain"
Antibodies to IFN-Gamma Receptor
Sergio et al. (2004) J. Immunol. 173:4000 "A Novel Mutation in IFN-gamma Receptor 2 with Dominant Negative Activity: Biological Consequences of Homozygous and Heterozygous States"
Conti et al. (2007) Immunobiology 109(6):2496 "In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth"