Non-human Primate Interferons

Rhesus/Cyno Interferon Alpha 2 Product 14110-1

Information: The cDNA for Rhesus/Cyno IFN-Alpha 2 was cloned from the Rhesus cell line LLC-MK2. This was found to be identical to the putative Rhesus IFN-Alpha 2 (XM_001107516) identified as part of the Rhesus genome project(www.hgsc.bcm.tmc.edu/projects/rmacaque). There are 14 amino acid differences in the mature protein (2 in the signal peptide) between the Rhesus and Human Alpha A (2a) sequence. There are 13 amino acid differences in the mature protein (2 in the signal peptide) between the Rhesus and Human Alpha 2 (2b) sequence. This is in accord with a previous report [Villinger et al. (1995) J. Immunol. 155:3946] stating that there are 15-16 amino acids different between the Rhesus IFN alpha 2 and human alpha 2 (2b) and human alpha A(2a) respectively

Cynomolgous Interferon Alpha 2 [Ile 16] Product 16110-1

Information: The cDNA for Cyno IFN-Alpha 2 was cloned from Cynomolgus (Macaca fascicularis) primary hepatocytes. Two sequences were identified, the first was found to be identical to the putative Rhesus IFN-Alpha 2 (XM_001107516) PBL Cat No. 14110 (Rhesus/Cyno IFN Alpha 2). The second, PBL Cat No. 16100-1 (Cynomolgus IFN Alpha 2 [Ile 16]), may represent an allelic form which differs from the Rhesus/Cyno Alpha 2 sequence by 1 amino acid. This version has Isoleucine at position 16 while the Rhesus/Cyno Alpha 2 has Methionine at position 16. Both forms were identified multiple times from the hepatocytes.